Endocrine Abstracts

Nowadays Chronic Obstructive Pulmonary Disease (COPD) is not considered a lung specific disease: nutritional alteration, weight loss due to increased energetic expenditure, loss of muscle mass are systemic effects, correlated with the risk of hospitalization due to exacerbation (AECOPD). AECOPD, characterised by augmented indexes like C reactive protein, interleukin-6, procalcitonin and serum amyloid A (SAA), negatively influenced natural history of the illness and were found ...

Introduction: Primary empty sella (PES) is a frequent ‘incidental’ finding reported in 5–25% of general population and is associated with endocrine abnormalities in 8–60% of cases. In this collaborative multicentric study we evaluated cardiovascular risk by assessing clinical characteristics, glucidic profile and lipid parameters.Design: A total of 94 PES patients (39M-55F; mean age 50.3±0.9 years; mean BMI 28.9±0.5 kg/m<sup...

Introduction: LADA is a heterogeneous population of diabetes subjects wherein subgroups can be identified based on their autoimmune status: the titre of autoantibodies to GAD.The aim of the study was to correlate, in LADA subjects, GADA titre, with the presence of other organ and non organ specific autoantibodies.Methods: LADA subjects (n=191) and type 2 diabetes (T2DM) subjects (n=382) were selected from the Non Insu...

Introduction: The etiology of the increased mortality seen in Prader–Willi syndrome (PWS) is not completely known. In this context, it has been suggested that central adrenal insufficiency (CAI) due to hypothalamic dysfunction may be responsible for unexplained deaths. However, data on hypothalamic-pituitary–adrenal (HPA) axis in PWS are still conflicting. Because adrenal insufficiency is a life-threatening disease, its diagnosis should be precise, urgent and reliabl...